GW25-e2344 Evaluation of apo A I, apo B, apo A I / apo B in the diagnosis of coronary heart disease
نویسندگان
چکیده
منابع مشابه
Apo B/apo A-I ratio and cardiovascular risk prediction.
Apolipoproteins are proteins associated with lipids in lipoprotein particles. They play important roles in lipoprotein metabolism, such as transport of these hydrophobic molecules in plasma aqueous medium, binding to specific receptors in cell surface to correctly direct lipids to target organs and body tissues, and activation or inhibition of enzymes involved in lipid metabolism. Apolipoprotei...
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Endogenous apolipoprotein E in VLDL is poorly expressed in receptor binding processes. Yet catabolism ofVLDL-remnants by cellular receptors depends on functional apo E molecules. To better understand remnant catabolism phenomena, we determined the metabolism of VLDL and post-lipolysis VLDL by cultured cells. Partial lipolysis was achieved by incubation of VLDL with lipoprotein lipase in vitro (...
متن کاملApo A-i and Apo E Interaction: beyond Lipoproteins
Apolipoproteins (Apo) A-I, A-II, A-IV, and E possess repeated amphipathic helical regions with the same genomic structure and are members of a multigene family that probably evolved from a common ancestral gene [1]. These apolipoproteins play pivotal roles in lipid transport and lipoprotein metabolism, and their carboxyl-terminal domain is critical for lipid binding [2]. The purpose of this com...
متن کاملApo B/Apo A-I ratio in central and peripheral arterial diseases.
BACKGROUND The apo B/apo A-I ratio represents the balance between atherogenic particles, rich in apo B, and the antiatherogenic ones, apo A-I rich. This study investigated the association between atherosclerotic diseases in different anatomical sites and apo B/apo A-I ratio. METHODS Lipids, lipoproteins, and apolipoproteins A-I and B were assessed in 30 subjects with coronary artery disease (...
متن کاملA novel homozygous missense mutation in the apo A-I gene with apo A-I deficiency.
We analyzed the genetic defect in a 67-year-old Japanese male patient with apolipoprotein (apo) A-I and high density lipoprotein (HDL) deficiencies, corneal opacities, and coronary artery disease. The plasma concentrations of apoA-I and HDL cholesterol were 2.9 to 7.3 mg/dL and 0.08 to 0.19 mmol/L, respectively. The lecithin:cholesterol acyltransferase (LCAT) activity and cholesterol esterifica...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2014.06.500